Harmonyca

What is Harmonyca?
HArmonyCa® is a next-generation injectable treatment that combines hyaluronic acid (HA) and calcium hydroxyapatite (CaHA) in a single syringe.
It was developed by Allergan Aesthetics and is designed to provide both immediate lifting/contouring and long-term collagen stimulation.
How HArmonyCa Works
1. Hyaluronic Acid (HA) – Immediate Effect
The HA component acts like a traditional filler:
  • Restores volume
  • Improves facial contours
  • Provides an immediate lifting effect
  • Hydrates the skin
Results are visible right after treatment.
2. Calcium Hydroxyapatite (CaHA) – Long-Term Effect
CaHA microspheres act as a biostimulator:
  • Stimulate fibroblasts
  • Increase natural collagen production
  • Improve skin firmness and elasticity
  • Continue working for months after treatment
This is why HArmonyCa is often called a hybrid filler or collagen-stimulating filler.
Areas Commonly Treated
HArmonyCa is mainly used in:
  • Cheeks
  • Jawline
  • Lower face
  • Pre-jowl area
  • Facial contouring
It is generally not recommended for lips, tear troughs, or very superficial wrinkles.
Ideal Candidates
Patients who:
  • Have mild to moderate skin laxity
  • Want a more defined jawline
  • Want facial lifting without surgery
  • Want collagen stimulation in addition to volume
  • Are typically in their late 30s, 40s, 50s, and beyond
It works particularly well for people noticing early jowling and loss of facial support.
Timeline of Results
  • Immediately: Lift and contour from HA
  • 1–3 months: Collagen production begins increasing
  • 3–6 months: Improved skin firmness and quality
  • Up to 12–24 months: Ongoing benefits depending on the patient and treatment plan

 

 

Potential Side Effects
Category Side Effects
Common
  • Swelling
  • Bruising
  • Tenderness
  • Redness
Less common
  • Nodules or lumps
  • Asymmetry
  • Vascular complications (rare but serious)
  • Over-contouring if too much product is used
Proper injection technique and patient selection are very important.
Important Consideration
Unlike a standard HA filler, only the hyaluronic acid portion can be dissolved with hyaluronidase.
The collagen-stimulating CaHA component cannot simply be dissolved once collagen formation has occurred.
This is why injector expertise is especially important
Feature Traditional HA Filler HArmonyCa
Immediate volume
Collagen stimulation Minimal Strong
Skin tightening Limited Better
Longevity 6–12 months 12–24 months
Facial support Good Excellent

HArmonyCa vs Sculptra

Feature HArmonyCa Sculptra
Immediate results Yes No
Collagen stimulation Yes Yes
Number of sessions Usually 1–2 Usually 2–4
Reversibility HA portion only Not reversible
Best for Lift + collagen Collagen restoration

 

HArmonyCa® Pre-Treatment Instructions
To minimize the risk of bruising and swelling:
  • Avoid alcohol for 24–48 hours before treatment.
  • Avoid aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), and other anti-inflammatory medications for 5–7 days if approved by your physician.
  • Avoid supplements that may increase bruising for 5–7 days, such as:
  • Fish oil/Omega-3
  • Vitamin E
  • Ginkgo biloba
  • Garlic supplements
  • Ginseng
  • St. John’s Wort
  • Stay well hydrated.
  • Inform your provider if you:
  • Are pregnant or breastfeeding.
  • Have an active skin infection, cold sore, rash, or acne breakout in the treatment area.
  • Have recently received dental work or are planning major dental procedures.
  • Have a history of severe allergies or autoimmune conditions.
  • Arrive with clean skin free of makeup if possible.
HArmonyCa® Post-Treatment Instructions
Time Frame Aftercare Instructions
First 24 Hours
  • Do not touch, massage, or apply pressure to the treated area unless specifically instructed by your provider.
  • Avoid strenuous exercise.
  • Avoid alcohol.
  • Avoid excessive facial movements or pressure on the treatment area.
  • Keep the area clean and avoid makeup for at least 12 hours.
First 48 Hours
  • Expect mild swelling, redness, tenderness, or bruising.
  • Apply a cool compress intermittently if needed.
  • Sleep with your head elevated the first night.
  • Avoid excessive heat exposure such as:
    • Hot tubs
    • Saunas
    • Steam rooms
    • Very hot showers
First 2 Weeks
  • Avoid facial treatments including:
    • Microneedling
    • Chemical peels
    • Laser treatments
    • Radiofrequency treatments
  • Avoid deep facial massage.
  • Protect your skin with sunscreen (SPF 30+).
What to Expect
Time Frame Expected Results
Immediately
  • Improved contour and lifting from the hyaluronic acid component.
  • Mild swelling may temporarily make the area appear fuller.
Within 1–3 Months
  • Gradual collagen stimulation begins.
  • Skin firmness and elasticity improve.
Within 3–6 Months
  • Continued improvement in skin quality and facial support.
  • More natural-looking rejuvenation as collagen develops.
Contact Your Provider Immediately If You Experience
  • Severe or worsening pain
  • Significant asymmetrical swelling
  • Skin blanching (white or gray discoloration)
  • Visual disturbances or blurred vision
  • Signs of infection:
  • Increasing redness
  • Warmth
  • Fever
  • Pus
These symptoms are uncommon but require urgent medical evaluation.