What is Harmonyca?

HArmonyCa® is a next-generation injectable treatment that combines hyaluronic acid (HA) and calcium hydroxyapatite (CaHA) in a single syringe.
It was developed by Allergan Aesthetics and is designed to provide both immediate lifting/contouring and long-term collagen stimulation.
How HArmonyCa Works
1. Hyaluronic Acid (HA) – Immediate Effect
The HA component acts like a traditional filler:
- Restores volume
- Improves facial contours
- Provides an immediate lifting effect
- Hydrates the skin
Results are visible right after treatment.
2. Calcium Hydroxyapatite (CaHA) – Long-Term Effect
CaHA microspheres act as a biostimulator:
- Stimulate fibroblasts
- Increase natural collagen production
- Improve skin firmness and elasticity
- Continue working for months after treatment
This is why HArmonyCa is often called a hybrid filler or collagen-stimulating filler.
Areas Commonly Treated
HArmonyCa is mainly used in:
- Cheeks
- Jawline
- Lower face
- Pre-jowl area
- Facial contouring
It is generally not recommended for lips, tear troughs, or very superficial wrinkles.
Ideal Candidates
Patients who:
- Have mild to moderate skin laxity
- Want a more defined jawline
- Want facial lifting without surgery
- Want collagen stimulation in addition to volume
- Are typically in their late 30s, 40s, 50s, and beyond
It works particularly well for people noticing early jowling and loss of facial support.
Timeline of Results
- Immediately: Lift and contour from HA
- 1–3 months: Collagen production begins increasing
- 3–6 months: Improved skin firmness and quality
- Up to 12–24 months: Ongoing benefits depending on the patient and treatment plan

Potential Side Effects
| Category | Side Effects |
|---|---|
| Common |
|
| Less common |
|
Proper injection technique and patient selection are very important.
Important Consideration
Unlike a standard HA filler, only the hyaluronic acid portion can be dissolved with hyaluronidase.
The collagen-stimulating CaHA component cannot simply be dissolved once collagen formation has occurred.
This is why injector expertise is especially important
| Feature | Traditional HA Filler | HArmonyCa |
|---|---|---|
| Immediate volume | ✓ | ✓ |
| Collagen stimulation | Minimal | Strong |
| Skin tightening | Limited | Better |
| Longevity | 6–12 months | 12–24 months |
| Facial support | Good | Excellent |
HArmonyCa vs Sculptra
| Feature | HArmonyCa | Sculptra |
|---|---|---|
| Immediate results | Yes | No |
| Collagen stimulation | Yes | Yes |
| Number of sessions | Usually 1–2 | Usually 2–4 |
| Reversibility | HA portion only | Not reversible |
| Best for | Lift + collagen | Collagen restoration |
HArmonyCa® Pre-Treatment Instructions
To minimize the risk of bruising and swelling:
- Avoid alcohol for 24–48 hours before treatment.
- Avoid aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), and other anti-inflammatory medications for 5–7 days if approved by your physician.
- Avoid supplements that may increase bruising for 5–7 days, such as:
- Fish oil/Omega-3
- Vitamin E
- Ginkgo biloba
- Garlic supplements
- Ginseng
- St. John’s Wort
- Stay well hydrated.
- Inform your provider if you:
- Are pregnant or breastfeeding.
- Have an active skin infection, cold sore, rash, or acne breakout in the treatment area.
- Have recently received dental work or are planning major dental procedures.
- Have a history of severe allergies or autoimmune conditions.
- Arrive with clean skin free of makeup if possible.
HArmonyCa® Post-Treatment Instructions
| Time Frame | Aftercare Instructions |
|---|---|
| First 24 Hours |
|
| First 48 Hours |
|
| First 2 Weeks |
|
What to Expect
| Time Frame | Expected Results |
|---|---|
| Immediately |
|
| Within 1–3 Months |
|
| Within 3–6 Months |
|
Contact Your Provider Immediately If You Experience
- Severe or worsening pain
- Significant asymmetrical swelling
- Skin blanching (white or gray discoloration)
- Visual disturbances or blurred vision
- Signs of infection:
- Increasing redness
- Warmth
- Fever
- Pus
These symptoms are uncommon but require urgent medical evaluation.

