What is Harmonyca?
HArmonyCa® is a next-generation injectable treatment that combines hyaluronic acid (HA) and calcium hydroxyapatite (CaHA) in a single syringe. It was developed by Allergan Aesthetics and is designed to provide both immediate lifting/contouring and long-term collagen stimulation.
How HArmonyCa Works
Hyaluronic Acid (HA)
The HA component acts like a traditional filler:
- Restores volume
- Improves facial contours
- Provides an immediate lifting effect
- Hydrates the skin
Results are visible right after treatment.
Calcium Hydroxyapatite (CaHA)
CaHA microspheres act as a biostimulator:
- Stimulate fibroblasts
- Increase natural collagen production
- Improve skin firmness and elasticity
- Continue working for months after treatment
This is why HArmonyCa is often called a hybrid filler or collagen-stimulating filler.
Timeline of Results
Lift and contour from HA
Collagen production begins increasing
Improved skin firmness and quality
Ongoing benefits depending on patient and treatment plan
Areas Commonly Treated
HArmonyCa is mainly used in:
Commonly Treated
- Cheeks
- Jawline
- Lower face
- Pre-jowl area
- Facial contouring
Generally Not Recommended For
- Lips
- Tear troughs
- Very superficial wrinkles
Ideal Candidates
Patients who:
- Have mild to moderate skin laxity
- Want a more defined jawline
- Want facial lifting without surgery
- Want collagen stimulation in addition to volume
- Are typically in their late 30s, 40s, 50s, and beyond
It works particularly well for people noticing early jowling and loss of facial support.
Potential Side Effects
| Category | Side Effects |
|---|---|
| Common | Swelling, Bruising, Tenderness, Redness |
| Less common | Nodules or lumps, Asymmetry, Vascular complications (rare but serious), Over-contouring if too much product is used |
Proper injection technique and patient selection are very important.
Important Consideration
Unlike a standard HA filler, only the hyaluronic acid portion can be dissolved with hyaluronidase.
The collagen-stimulating CaHA component cannot simply be dissolved once collagen formation has occurred.
This is why injector expertise is especially important.
Treatment Timeline: Before & After
HArmonyCa® Pre-Treatment and Post-Treatment Instructions, in order.
HArmonyCa® Pre-Treatment Instructions
To minimize the risk of bruising and swelling:
- Avoid alcohol for 24–48 hours before treatment.
- Avoid aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), and other anti-inflammatory medications for 5–7 days if approved by your physician.
- Avoid supplements that may increase bruising for 5–7 days, such as:
- Fish oil/Omega-3
- Vitamin E
- Ginkgo biloba
- Garlic supplements
- Ginseng
- St. John’s Wort
- Stay well hydrated.
- Inform your provider if you:
- Are pregnant or breastfeeding.
- Have an active skin infection, cold sore, rash, or acne breakout in the treatment area.
- Have recently received dental work or are planning major dental procedures.
- Have a history of severe allergies or autoimmune conditions.
- Arrive with clean skin free of makeup if possible.
First 24 Hours
- Do not touch, massage, or apply pressure to the treated area unless instructed.
- Avoid strenuous exercise.
- Avoid alcohol.
- Avoid excessive facial movements.
- Keep area clean and avoid makeup for 12 hours.
First 48 Hours
- Swelling, redness, bruising may occur.
- Use cool compress if needed.
- Sleep with head elevated.
- Avoid heat (saunas, hot tubs, steam rooms).
First 2 Weeks
- Avoid microneedling, lasers, chemical peels, RF treatments.
- Avoid deep facial massage.
- Use SPF 30+ sunscreen.
What to Expect
Improved contour and lifting from HA
Collagen stimulation begins
Skin firmness improves
Contact Your Provider Immediately If You Experience
- Severe or worsening pain
- Significant asymmetrical swelling
- Skin blanching (white/gray discoloration)
- Visual disturbances or blurred vision
- Signs of infection (redness, warmth, fever, pus)
These symptoms are uncommon but require urgent medical evaluation.